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Silva Lab at Washington University in St. Louis

Watching Ion Channels Move

Voltage-clamp fluorometry is a recent technique in which fluorescence from a specific protein site and ionic current are tracked simultaneously to infer mechanism

Voltage Clamp Fluorometry

HoloLens in the Cardiac Catherization Lab at St. Louis Children's Hospital

Jon Silva, PhD and Jennifer Silva, MD are developing a new technology to increase accuracy and safety in the Cardiac Cath Lab at St. Louis Children's Hospital.

New Therapeutic Approach

Sunrise over Washington University

Our Motivation

Cardiac arrhythmias are often caused at the molecular level by genetic mutations or drugs that affect the heart rhythm. While molecules interact at nanometer and nanosecond time-scales, the heart beat travels over centimeters over seconds. Bridging this time and spatial scale gap is a primary barrier to understanding arrhythmia and developing therapies.

Common heart ailment target of new WashU Engineering research

Common heart ailment target of new WashU Engineering research

"Jonathan Silva, assistant professor of biomedical engineering in the School of Engineering & Applied Science, will conduct the research with a five-year, $1.9 million grant from the National Heart, Lung, and Blood Institute of the National Institutes of Health. Specifically, Silva and his team will study how small molecules and proteins interact with ion channels in the heart to cause and prevent arrhythmia, when the heart beats too fast, too slow, or is too unstable."

Jonathan Silva PhD

Jonathan Silva PhD

Contact Information:
(314) 935-8837
jonsilva@wustl.edu
Whitaker Hall

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