Publications

2019

Moreno J. D., Zhu W., Mangold K., Chung W., Silva J. R., (2019). A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target. JACC: Basic to Translational Science. https://doi.org/10.1016/j.jacbts.2019.06.002 

2018

Zhu W., Mazzanti A., Voelker T., Hou P., Moreno J. D.Angsutararux P., Naegle K. M., Priori S. G., Silva J. R., (2018). Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome. Circulation Research. https://doi.org/10.1161/CIRCRESAHA.118.314050

2017

Mangold K. E., Silva J. R., (2017). Mechanisms and Models of Cardiac Sodium Channel Inactivation. Channels. http://dx.doi.org/10.1080/19336950.2017.1369637

Zhu W., Silva, J. R. (2017). Mechanisms of noncovalent β subunit regulation of NaV channel gating. Journal of General Physiology, 149(8) https://doi.org/10.1085/jgp.201711802

Hsu, E.J., Silva, J. R. (2017). Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. Journal of General Physiology, 149(3), https://doi.org/10.1085/jgp.201611678

2016

Teed, Z. R., Silva, J. R. (2016). A computationally efficient algorithm for fitting ion channel parameters. MethodsX, 3, 577-588.   https://dx.doi.org/10.1016/j.mex.2016.11.001

Wang, H.-G., Zhu, W., Kanter, R. J., Silva, J. R., Honeywell, C., Gow, R. M., & Pitt, G. S. (2016). A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. Journal of Molecular and Cellular Cardiology, 92, 52–62. http://doi.org/10.1016/j.yjmcc.2016.01.014

Zhu, W., Varga, Z., & Silva, J. R. (2016). Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry. Progress in Biophysics and Molecular Biology, 120(1-3), 3–17. http://doi.org/10.1016/j.pbiomolbio.2015.12.003

2015

Brettmann, J. B., Urusova, D., Tonelli, M., Silva, J. R., & Henzler-Wildman, K. A. (2015). Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. Proc Natl Acad Sci U S A, 112(50), 15366–15371. http://doi.org/10.1073/pnas.1515965112

Varga, Z., Zhu, W., Schubert, A. R., Pardieck, J. L., Krumholz, A., Hsu, E. J., … Silva, J. R. (2015). Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation. Arrhythmia and Electrophysiology, 8(5), 1228–39. http://doi.org/10.1161/CIRCEP.115.003155

2014

Silva, J. R., Cooper, P., & Nichols, C. G. (2014). Modeling K,ATP-dependent excitability in pancreatic islets. Biophysical Journal, 107(9), 2016–2026. http://doi.org/10.1016/j.bpj.2014.09.037

Rudokas, M. W., Varga, Z., Schubert, A. R., Asaro, A. B., & Silva, J. R. (2014). The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry. Journal of Visualized Experiments, 85, 1–11. http://dx.doi.org/10.3791/51040

Silva, J. R. (2014). Voltage Gated Sodium Channels. Handbook of Experimental Pharmacology, 221, 7–32. http://doi.org/10.1007/978-3-642-41588-3

2013

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology, 141(3), 323–34. http://doi.org/10.1085/jgp.201210910

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4. The Journal of General Physiology, 141(3), 309–21. http://doi.org/10.1085/jgp.201210909

Zaydman, M. A., Silva, J. R., Delaloye, K., Li, Y., Liang, H., Larsson, H. P., … Cui, J. (2013). Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 13180–5. http://doi.org/10.1073/pnas.1305167110

2012

Silva, J. N. A., & Silva, J. R. (2012). Updates on the inherited cardiac ion channelopathies: From cell to clinical. Current Treatment Options in Cardiovascular Medicine, 14(5), 473–489. http://doi.org/10.1007/s11936-012-0198-1