Publications

2017

Hsu, E.J., Silva, J. R. (2017). Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. Journal of General Physiology, 149(3), https://doi.org/10.1085/jgp.201611678

2016

Teed, Z. R., Silva, J. R. (2016). A computationally efficient algorithm for fitting ion channel parameters. MethodsX, 3, 577-588.   https://dx.doi.org/10.1016/j.mex.2016.11.001

Wang, H.-G., Zhu, W., Kanter, R. J., Silva, J. R., Honeywell, C., Gow, R. M., & Pitt, G. S. (2016). A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. Journal of Molecular and Cellular Cardiology, 92, 52–62. http://doi.org/10.1016/j.yjmcc.2016.01.014

Zhu, W., Varga, Z., & Silva, J. R. (2016). Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry. Progress in Biophysics and Molecular Biology, 120(1-3), 3–17. http://doi.org/10.1016/j.pbiomolbio.2015.12.003

2015

Brettmann, J. B., Urusova, D., Tonelli, M., Silva, J. R., & Henzler-Wildman, K. A. (2015). Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. Proc Natl Acad Sci U S A, 112(50), 15366–15371. http://doi.org/10.1073/pnas.1515965112

Varga, Z., Zhu, W., Schubert, A. R., Pardieck, J. L., Krumholz, A., Hsu, E. J., … Silva, J. R. (2015). Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation. Arrhythmia and Electrophysiology, 8(5), 1228–39. http://doi.org/10.1161/CIRCEP.115.003155

2014

Silva, J. R., Cooper, P., & Nichols, C. G. (2014). Modeling K,ATP-dependent excitability in pancreatic islets. Biophysical Journal, 107(9), 2016–2026. http://doi.org/10.1016/j.bpj.2014.09.037

Rudokas, M. W., Varga, Z., Schubert, A. R., Asaro, A. B., & Silva, J. R. (2014). The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry. Journal of Visualized Experiments, 85, 1–11. http://dx.doi.org/10.3791/51040

Silva, J. R. (2014). Voltage Gated Sodium Channels. Handbook of Experimental Pharmacology, 221, 7–32. http://doi.org/10.1007/978-3-642-41588-3

2013

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology, 141(3), 323–34. http://doi.org/10.1085/jgp.201210910

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4. The Journal of General Physiology, 141(3), 309–21. http://doi.org/10.1085/jgp.201210909

Zaydman, M. A., Silva, J. R., Delaloye, K., Li, Y., Liang, H., Larsson, H. P., … Cui, J. (2013). Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 13180–5. http://doi.org/10.1073/pnas.1305167110

2012

Silva, J. N. A., & Silva, J. R. (2012). Updates on the inherited cardiac ion channelopathies: From cell to clinical. Current Treatment Options in Cardiovascular Medicine, 14(5), 473–489. http://doi.org/10.1007/s11936-012-0198-1