2020

Southworth M. K., Silva J. N. A., Blume W. M., Hare G. F. V., Dalal A. S. and Silva J. R., “Performance Evaluation of Mixed Reality Display for Guidance during Transcatheter Cardiac Mapping and Ablation”, IEEE Journal of Translational Engineering in Health and Medicine, https://doi.org/10.1109/JTEHM.2020.3007031.

Zhu W, Li T, Silva J.R., Chen J, “Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms”, Scientific Reports, 2020.

Silva JNA, Southworth MK, Blume WM, Andrews C. M., Van Hare GF, Dalal AS, Miller M, Sodhi SS, Silva J. R., “First-In-Human Use of a Mixed Reality Display for Guidance during Transcatheter Cardiac Mapping and Ablation”, JACC: Electrophysiology. 2020.

Silva JNA, Privitera MB, Southworth MK, Silva J. R., Development and Human Factors Considerations for Extended Reality Applications in Medicine: The Enhanced ELectrophysiology Visualization and Interaction System (ĒLVIS). Human Computer Interaction International Conference Proceedings, 2020.

2019

Salvage SC, Zhu W, Habib ZF, Hwang SS, Irons JR, Huang CL*, Silva J. R.*, Jackson AP*. Gating control of the cardiac sodium channel Nav1. 5 by its β3-subunit involves distinct roles for a transmembrane glutamic acid and the extracellular domain. Journal of Biological Chemistry. 2019 Dec 20;294(51):19752-63. *Co-corresponding authors. https://doi.org/10.1074/jbc.RA119.010283

Moreno J. D., Zhu W.Mangold K., Chung W., Silva J. R., (2019). A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target. JACC: Basic to Translational Science. https://doi.org/10.1016/j.jacbts.2019.06.002 

2018

Zhu W., Mazzanti A., Voelker T., Hou P., Moreno J. D.Angsutararux P., Naegle K. M., Priori S. G., Silva J. R., (2018). Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome. Circulation Research. https://doi.org/10.1161/CIRCRESAHA.118.314050

2017

Mangold K. E., Silva J. R., (2017). Mechanisms and Models of Cardiac Sodium Channel Inactivation. Channels. http://dx.doi.org/10.1080/19336950.2017.1369637

Zhu W.Silva, J. R. (2017). Mechanisms of noncovalent β subunit regulation of Nachannel gating. Journal of General Physiology, 149(8) https://doi.org/10.1085/jgp.201711802

Hsu, E.J., Silva, J. R. (2017). Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. Journal of General Physiology, 149(3), https://doi.org/10.1085/jgp.201611678

2016

Teed, Z. R., Silva, J. R. (2016). A computationally efficient algorithm for fitting ion channel parameters. MethodsX, 3, 577-588.   https://dx.doi.org/10.1016/j.mex.2016.11.001

Wang, H.-G., Zhu, W., Kanter, R. J., Silva, J. R., Honeywell, C., Gow, R. M., & Pitt, G. S. (2016). A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. Journal of Molecular and Cellular Cardiology, 92, 52–62. http://doi.org/10.1016/j.yjmcc.2016.01.014

Zhu, W.Varga, Z., & Silva, J. R. (2016). Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry. Progress in Biophysics and Molecular Biology, 120(1-3), 3–17. http://doi.org/10.1016/j.pbiomolbio.2015.12.003

2015

Brettmann, J. B., Urusova, D., Tonelli, M., Silva, J. R., & Henzler-Wildman, K. A. (2015). Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. Proc Natl Acad Sci U S A, 112(50), 15366–15371. http://doi.org/10.1073/pnas.1515965112

Varga, Z.Zhu, W.Schubert, A. R.Pardieck, J. L.Krumholz, A.Hsu, E. J., … Silva, J. R. (2015). Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation. Arrhythmia and Electrophysiology, 8(5), 1228–39. http://doi.org/10.1161/CIRCEP.115.003155

2014

Silva, J. R., Cooper, P., & Nichols, C. G. (2014). Modeling K,ATP-dependent excitability in pancreatic islets. Biophysical Journal, 107(9), 2016–2026. http://doi.org/10.1016/j.bpj.2014.09.037

Rudokas, M. W.Varga, Z.Schubert, A. R.Asaro, A. B., & Silva, J. R. (2014). The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry. Journal of Visualized Experiments, 85, 1–11. http://dx.doi.org/10.3791/51040

Silva, J. R. (2014). Voltage Gated Sodium Channels. Handbook of Experimental Pharmacology, 221, 7–32. http://doi.org/10.1007/978-3-642-41588-3

2013

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology, 141(3), 323–34. http://doi.org/10.1085/jgp.201210910

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4. The Journal of General Physiology, 141(3), 309–21. http://doi.org/10.1085/jgp.201210909

Zaydman, M. A., Silva, J. R., Delaloye, K., Li, Y., Liang, H., Larsson, H. P., … Cui, J. (2013). Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 13180–5. http://doi.org/10.1073/pnas.1305167110

2012

Silva, J. N. A., & Silva, J. R. (2012). Updates on the inherited cardiac ion channelopathies: From cell to clinical. Current Treatment Options in Cardiovascular Medicine, 14(5), 473–489. http://doi.org/10.1007/s11936-012-0198-1