Moreno J. D., Zhu W., Mangold K., Chung W., Silva J. R., (2019). A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target. JACC: Basic to Translational Science. 


Zhu W., Mazzanti A., Voelker T., Hou P., Moreno J. D.Angsutararux P., Naegle K. M., Priori S. G., Silva J. R., (2018). Predicting Patient Response to the Antiarrhythmic Mexiletine Based on Genetic Variation: Personalized Medicine for Long QT Syndrome. Circulation Research.


Mangold K. E., Silva J. R., (2017). Mechanisms and Models of Cardiac Sodium Channel Inactivation. Channels.

Zhu W., Silva, J. R. (2017). Mechanisms of noncovalent β subunit regulation of NaV channel gating. Journal of General Physiology, 149(8)

Hsu, E.J., Silva, J. R. (2017). Regulation of Na+ channel inactivation by the DIII and DIV voltage-sensing domains. Journal of General Physiology, 149(3),


Teed, Z. R., Silva, J. R. (2016). A computationally efficient algorithm for fitting ion channel parameters. MethodsX, 3, 577-588.

Wang, H.-G., Zhu, W., Kanter, R. J., Silva, J. R., Honeywell, C., Gow, R. M., & Pitt, G. S. (2016). A novel NaV1.5 voltage sensor mutation associated with severe atrial and ventricular arrhythmias. Journal of Molecular and Cellular Cardiology, 92, 52–62.

Zhu, W., Varga, Z., & Silva, J. R. (2016). Molecular motions that shape the cardiac action potential: Insights from voltage clamp fluorometry. Progress in Biophysics and Molecular Biology, 120(1-3), 3–17.


Brettmann, J. B., Urusova, D., Tonelli, M., Silva, J. R., & Henzler-Wildman, K. A. (2015). Role of protein dynamics in ion selectivity and allosteric coupling in the NaK channel. Proc Natl Acad Sci U S A, 112(50), 15366–15371.

Varga, Z., Zhu, W., Schubert, A. R., Pardieck, J. L., Krumholz, A., Hsu, E. J., … Silva, J. R. (2015). Direct Measurement of Cardiac Na+ Channel Conformations Reveals Molecular Pathologies of Inherited Mutations. Circulation. Arrhythmia and Electrophysiology, 8(5), 1228–39.


Silva, J. R., Cooper, P., & Nichols, C. G. (2014). Modeling K,ATP-dependent excitability in pancreatic islets. Biophysical Journal, 107(9), 2016–2026.

Rudokas, M. W., Varga, Z., Schubert, A. R., Asaro, A. B., & Silva, J. R. (2014). The Xenopus Oocyte Cut-open Vaseline Gap Voltage-clamp Technique With Fluorometry. Journal of Visualized Experiments, 85, 1–11.

Silva, J. R. (2014). Voltage Gated Sodium Channels. Handbook of Experimental Pharmacology, 221, 7–32.


Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels II: a periodic paralysis mutation in Na(V)1.4 (L689I). The Journal of General Physiology, 141(3), 323–34.

Silva, J. R., & Goldstein, S. A. N. (2013). Voltage-sensor movements describe slow inactivation of voltage-gated sodium channels I: Wild-type skeletal muscle NaV1.4. The Journal of General Physiology, 141(3), 309–21.

Zaydman, M. A., Silva, J. R., Delaloye, K., Li, Y., Liang, H., Larsson, H. P., … Cui, J. (2013). Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proceedings of the National Academy of Sciences of the United States of America, 110(32), 13180–5.


Silva, J. N. A., & Silva, J. R. (2012). Updates on the inherited cardiac ion channelopathies: From cell to clinical. Current Treatment Options in Cardiovascular Medicine, 14(5), 473–489.